This picture alludes to the scene of Calvary in how Jesus literally picked up his cross. Continuing with some of the same imagery, Princess Peach and Toad act as stand-ins for Jesus' disciples, while Bowser (representing Satan) and Wario (representing the anti-Christ) look on the scene with glee. Mario (representing Jesus) is carrying the bomb, which represents Jesus' cross- the cross which all believers are called to bear. 

“If anyone would come after me, let him deny himself and take up his cross daily and follow me. For whoever would save his life will lose it, but whoever loses his life for my sake will save it. For what does it profit a man if he gains the whole world and loses or forfeits himself?" Luke 9:23-25